175 Understanding immune privilege in an inducible mouse model of primary cicatrcial alopecia

Primer Cicatricial Alopecias (PCAs) are a group of autoinflammatory disorders characterized by scarring the hair follicle and result is irreversible loss. CD8+ T cells attack epithelial stem (eHFSCs) in bulge follicle, fibrosis ultimately leads to Immune privilege collapse plays role pathogenesis alopecia areata, though its loss not fully characterized. We developed an inducible mouse model that exhibits skin using adoptive transfers OT1 into autoimmune prone host expresses ovalbumin under control keratin 5 promoter. examined biopsies for histology, NanoString inflammation immunology target gene expression flow cytometry quantification immune filtrates from compared these human datasets. Our data showed CD200R significantly reduced affected skin. Previous studies suggest CD200-CD200R signaling pathway immunoregulatory protects attack. Comparison this published datasets revealed overlap with LPP, CCCA DLE. plan continue examining breakdown as it pertains cells, goal identifying novel treatment targets alopecia.